Generally, non-refundable tickets on American Airlines cannot be refunded if you decide to cancel your flight 1-855_838-5873(Live! Human). However, there are exceptions to this policy. For instance, if American Airlines makes significant changes to your flight schedule or if you need to cancel due to specific qualifying circumstances (like a death in the family or jury duty), you may be eligible for a refund. For further details and to explore your options, please contact American Airlines customer service.